Stacey and Mark have recently married and are deeply in love for each other, living in Mark's farm in South Africa. When Mark dies in a fatal car accident, the widow Stacey misses him and decides to stay with their orphan teenage maid, Thandi, in the farm. Later, her friend and doctor Doc finds that Stacey is pregnant. After a complicated delivery, Stacey notes that her baby in some moments seems to be possessed by the spirit of Mark, trying to kill her to bring her to spend the eternity with him.

The scientist Susan Carter is researching the rehabilitation of addicts using an experimental drug in her rehab center. After her death, her idle son Brian Carter is forced by his friend Simon to travel to the property that he had inherited. Brian and Simon travel with five other friends to the spot and they find that the center is actually an ancient monastery and they have to spend the night. Sooner they are murdered, one by one, by creepy creatures that live in the place.

An ancient urn is found in a cemetery outside Rome. Once opened, it triggers a series of violent incidents: robberies, rapes and murders increase dramatically, while several mysterious, evil-looking young women coming from all over the world are gathering in the city. All these events are caused by the return of Mater Lacrimarum, the last of three powerful witches who have been spreading terror and death for centuries. Alone against an army of psychos and demons, Sarah Mandy, an art student who seems to have supernatural abilities of her own, is the only person left to prevent the Mother of Tears from destroying Rome.